Categories
Law Term

Gain-Of-Function

Definition of Gain-Of-Function:

Gain-Of-Function (GOF) research describes a type of research that modifies a biological agent so that it confers new or enhanced activity to that agent. GOF research is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e. the types of hosts that a microorganism can infect.

Certain gain-of-function studies with the potential to enhance the pathogenicity or transmissibility of potential pandemic pathogens (PPPs) have raised biosafety and biosecurity concerns, including the potential dual-use risks associated with the misuse of the information or products resulting from such research.